I usually have to take ibuprofen for menstrual cramps. The ibuprofen is supposed to work for an entire 4 hours, but does it really last that long? No.... Of course it always wears off at 3 hours.
I've found that if I also take magnesium it really helps with my cramps. I buy this kind: Country Life Chelated Magnesium 250mg and I take one pill once or twice a day. Yes, the magnesium has the side effect of making me sleepy... but at least I'm not in pain. No other side effects from the magnesium though. It actually has a pretty calming effect on my mood, and I also occasionally take it for insomnia or for the kind of mood (sometimes a PMS one) where I'm very tearful. It just seems to help clear up the tears!
Here's a link to someone else who found magnesium helpful for cramps. My internet searching mostly turns up stuff about magnesium deficiency linked to menstrual cramps, and I don't know if that has anything to do with the efficacy of magnesium..... I think it might have to do with magnesium causing muscle relaxation.
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